Journal Title：Journal Of Medicinal Chemistry

The Journal of Medicinal Chemistry publishes studies that contribute to an understanding of the relationship between molecular structure and biological activity or mode of action.

Some specific areas that are appropriate include the following:

* Design, synthesis, and biological evaluation of novel biologically active compounds, diagnostic agents, or labeled ligands employed as pharmacological tools.

* Molecular modifications of reported series that lead to a significantly improved understanding of their structure-activity relationships (SAR). Routine extensions of existing series that do not utilize novel chemical or biological approaches or do not add significantly to a basic understanding of the SAR of the series will normally not be accepted for publication.

*Structural biological studies (X-ray, NMR, etc.) of relevant ligands and targets with the aim of investigating molecular recognition processes in the action of biologically active compounds.

* Molecular biological studies (e.g., site-directed mutagenesis) of macromolecular targets that lead to an improved understanding of molecular recognition.

*Computational studies that provide fresh insight into the SAR of compound series that are of current general interest or analysis of other available data that subsequently advance medicinal chemistry knowledge.

* Substantially novel computational chemistry methods with demonstrated value for the identification, optimization, or target interaction analysis of bioactive molecules.

* Effect of molecular structure on the distribution, pharmacokinetics, and metabolic transformation of biologically active compounds. This may include design, synthesis, and evaluation of novel types of prodrugs.

* Novel methodology with broad application to medicinal chemistry, but only if the methods have been tested on relevant molecules.

《藥物化學雜志》發(fā)表的研究有助于理解分子結構與生物活性或作用方式之間的關系。

一些適當?shù)奶囟I域包括：

* 設計、合成和生物學評估用作藥理學工具的新型生物活性化合物、診斷劑或標記配體。

* 對已報道的系列進行分子修飾，從而顯著提高對其結構-活性關系 (SAR) 的理解。現(xiàn)有系列的常規(guī)擴展，如果不采用新的化學或生物學方法，或者沒有顯著增加對系列 SAR 的基本理解，通常不會被接受出版。

*相關配體和靶標的結構生物學研究（X 射線、NMR 等），旨在研究生物活性化合物作用中的分子識別過程。

*大分子靶標的分子生物學研究（例如，定點誘變），可提高對分子識別的理解。

*計算研究，為當前普遍感興趣的化合物系列的 SAR 提供新的見解，或分析其他可用數(shù)據(jù)，從而促進藥物化學知識。

*具有顯著價值的實質上新穎的計算化學方法，可用于生物活性分子的鑒定、優(yōu)化或靶標相互作用分析。

*分子結構對生物活性分子的分布、藥代動力學和代謝轉化的影響化合物。這可能包括新型前體藥物的設計、合成和評估。

* 廣泛應用于藥物化學的新方法，但前提是這些方法已經在相關分子上進行了測試。

Journal Of Medicinal Chemistry創(chuàng)刊于1959年，由American Chemical Society出版商出版，收稿方向涵蓋醫(yī)學 - 醫(yī)藥化學全領域，在行業(yè)領域中學術影響力很大，屬于TOP期刊，國際一流期刊，關注度和專業(yè)度非常高，所以對原創(chuàng)文章要求創(chuàng)新性很高，過審難度很高，如果您有志于TOP期刊，建議關注此刊。平均審稿速度 約2.1個月 ，影響因子指數(shù)6.8，該期刊近期沒有被列入國際期刊預警名單，廣大學者值得一試。